Dr David Danish

What Does the Research Say About Autism Risk During Pregnancy?

Several recent studies have explored whether specific maternal health factors—like gestational diabetes or infections—may contribute to autism risk. The findings do show some associations, but how these data are reported, especially in popular media, can shape public perception more than the numbers themselves.

Is Gestational Diabetes Linked to Autism?

There is a consistent signal in the research: mothers with gestational diabetes mellitus (GDM) tend to have children with slightly higher odds of neurodevelopmental conditions, including ADHD and, in some cases, autism.

  • A large meta-analysis of 24 studies found a 53% increased risk of autism in children born to mothers with diabetes—but that risk dropped significantly once researchers adjusted for important variables like income, overall maternal health, and genetic factors [1].
  • Other studies found that behavioral challenges and ADHD symptoms were more prevalent in children with prenatal GDM exposure, though again, those associations often diminished when family and environmental contexts were considered [2].

So, are these findings real? Yes. The statistics are meaningful. But the way they’re framed—especially in headlines—can make them feel more definitive than they are. Associations don’t automatically mean causation, and the presence of risk doesn’t imply fault or failure.

🧠 Dr. Danish’s Take:
“We have to be careful with how we talk about risk. These studies don’t prove that diabetes during pregnancy causes autism. They point to complex relationships that likely involve genetics, environment, and biology. Moms aren’t to blame—and most risk factors are well outside anyone’s control.”


What About Genetics? A Massive Danish Study Brings Context

One of the most informative pieces of research comes from a 2025 Danish cohort study following more than 1.1 million children.

This study initially showed higher rates of autism in children whose mothers had conditions like diabetes, depression, or infections. But then researchers took a closer look—using sibling comparisons to see what role family traits might play.

Key insights:

  • When comparing siblings—one exposed to a maternal health condition and the other not—the increased risk of autism often disappeared or was significantly reduced [3].
  • This suggests that shared genetics or family environment, rather than the specific health condition itself, may be the underlying driver of the observed risk.

That doesn’t mean the original correlations were meaningless—but it does mean we need to interpret them with care.

🧠 Dr. Danish’s Take:
“Genetics aren’t destiny, but they matter. And what this study shows is that a diagnosis like autism often reflects layers of vulnerability—not a single cause. Risk isn’t something a mother creates or controls; it’s something we try to understand, reduce where we can, and support through informed care.”


Conflicting data is part of the scientific process. Here’s why some studies continue to report stronger links:

  • Sample size and study design: Smaller or less rigorous studies may overestimate associations.
  • Inconsistent definitions: What counts as autism or diabetes can vary across studies.
  • Timing of evaluation: Shorter follow-up windows may miss developmental symptoms that emerge later.

Importantly, the most robust and well-controlled studies—especially those that account for family factors—tend to find weaker, more nuanced associations. This doesn’t erase the findings, but it helps us interpret them responsibly.


What You Can Learn from Dr. Danish

At the heart of all this research is a powerful truth:

  • Autism arises from many factors—not one decision, diagnosis, or event.
  • Most of these factors are outside any parent’s control.
  • Blame is never helpful. Understanding is.

Whether you’re planning for a healthy pregnancy, seeking answers about your child’s development, or exploring a diagnosis, Dr. Danish offers a calm, evidence-based voice in a sea of conflicting information.

You deserve guidance that empowers you—not frightens you.


Explore More from Dr. Danish

➤ Learn more in the Mind Vault — your free gateway to smarter, evidence-based mental health content
➤ Check out Dr. Danish’s supplement guide for trusted, research-backed recommendations
➤ Consider ADHD coaching options — available globally, no matter where you live
➤ Access in-person care through the Philadelphia Integrative Psychiatry team
➤ For NYC-based care, visit New York Integrative Psychiatry
➤ Curious about sleep and pregnancy? Check out SleepScriptMD — fast, effective virtual sleep treatment

If this article helped clarify something for you, bookmark it, share it, or explore more tools to support your mental health journey.


Meta Description:

Is autism caused by pregnancy complications? Learn what new research actually says about diabetes, genetics, and autism risk—without fear or misinformation.


Sources:

  1. https://www.sciencedirect.com/science/article/pii/S0149763422000811
  2. https://pubmed.ncbi.nlm.nih.gov/39891002/
  3. https://pubmed.ncbi.nlm.nih.gov/39885386/