Vitamin B6 plays a key role in neurotransmitter synthesis and may help balance mood swings, especially related to hormonal changes.

Microdoses of lithium orotate are sometimes used to reduce irritability and mood volatility, particularly in sensitive individuals.

Saffron may enhance mood stability through its effects on serotonin and antioxidant pathways.

Omega-3s support emotional regulation and have shown benefits in reducing mood instability, especially in bipolar spectrum conditions.